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The Duffy-null phenotype is a genetic variant tied to ancestry, not race, most commonly found in people with West African ancestry. In the United States, about two-thirds of people who self-identify as Black carry this variant. Individuals with the Duffy-null phenotype naturally have lower neutrophil (white blood cell) levels without an increased risk of infection. But because neutrophil reference ranges were historically based on people of European descent, failing to account for this variant h
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