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Platelets circulate in the bloodstream in an inactive form. When a blood vessel is damaged, the inner wall exposes collagen and other materials that normally remain hidden. Platelets have surface receptors that detect these exposed structures. As soon as they bind to the collagen, they become activated. Activation causes the platelets to change shape, swell slightly, and extend small projections that help them stick together. Activated platelets release chemical signals that attract more platele
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