No special prep — learn about colon cancer screening with the Cologuard test. A Cologuard test is intended to screen adults 45 and older at average risk for colorectal cancer. Do not use if you have had adenomas, have inflammatory bowel disease and certain hereditary syndromes, or a personal or family history of colorectal cancer. Cologuard is not a replacement for colonoscopy in high risk patients. Cologuard performance in adults ages 45-49 is estimated based on a large clinical study of patien