🩸 Tranexamic Acid (TXA) – How does it actually work? When trauma patients bleed, their body forms clots to stop the loss. But the body also activates fibrinolysis – the natural breakdown of clots. In major haemorrhage this can become overactive, leading to clot breakdown before bleeding is controlled. 👉 TXA works by blocking plasminogen from converting into plasmin, the enzyme that dissolves fibrin clots. 👉 This helps stabilise clots, reduce bleeding, and improve survival if given within 3 ho