BIOCHEMISTRY TOOL TO TAKE 20 g CREATINE WITHOUT GI DISTRESS How much creatine you can fully dissolve in 500 mL to reduce GI distress (use water and/or heat to scale): 4°C (39°F): ~3 g 20°C (68°F): ~7 g 50°C (122°F): ~17 g 60°C (140°F): ~22.5 g Over 60°C (closer to 70) and you get a rapid breakdown of creatine to creatinine. Paper referenced near beginning - PMID: 21424716 | William Wallace, Ph.D.
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