How can the multifunctional factor Sonic Hedgehog (SHH) elicit specific responses from its target cells? A study now pinpoints proteoglycans as crucial anchors and modulators of SHH signaling, ...

Biomimetic Proteoglycans Augment the Cellular Microniche in Cartilage and Serve as a Drug Delivery Platform for Potential Disease Modifying Osteoarthritis Drugs Osteoarthritis (OA) is the most common ...

Proteoglycans—molecules consisting of a core protein with multiple sugar chains—are so complex that researchers usually study the protein and sugar components separately, which makes it difficult to ...

Aggrecan, a major component of proteoglycan (PG) having chondroitin sulfate (CS) in cartilaginous tissues, has become increasingly popular as an ingredient in health food. In fact, proteoglycans from ...

A recent study has uncovered the essential roles of two proteoglycans, biglycan and decorin, in maintaining bone mass, water retention, and bulk/in situ mechanical competence. Through the use of ...

Biochemistry research on lectins and proteoglycans have been around as long as Frank Sinatra tunes. So finding out that these proteins interact is like discovering Sinatra and Elvis started a band way ...

Complex sugar-protein molecules that sense external messages to help a cell grow or respond to its environment can now be tracked and analyzed, using a Nobel Prize-winning chemistry technique.

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin. These proteoglycans ...