"To date, the most successful approaches deploy neural networks. Our goal was to develop a training-free pipeline for binder design. We wanted a design pipeline that not only enables the creation of ...

An illustration of antibodies, colored pink and blue, over a white background. Antibodies’ flexible loop structures make them difficult to crack with artificial intelligence. Credit: Ian C.

The Baker lab at the Institute for Protein Design at the University of Washington School of Medicine continues to drive innovation in AI-driven advances for protein design. This time, the team used ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

For the field of drug development, hitting the right target with atomic precision to achieve therapeutic effect remains the core challenge. While traditional R&D pipelines are dependent on ...