In the evolutionary history of life, the ability of a cell to separate its inner world from the external environment was an ...

For years, biomolecular condensates were thought to be simple, liquid-like droplets with little internal organization. New ...

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger ...

Membrane proteins are key targets for therapeutic intervention using antibody biologics. Over 60% of FDA-approved drugs act on these proteins. Studying them is challenging because the proteins must be ...

Scientists have attempted to map the human cell since the first microscope was invented more than 400 years ago. But many components of the cell still remain uncharted. " We know each of the proteins ...

Scientists link TMC protein membrane disruption to hearing loss, showing how mutations, drugs and noise trigger hair cell death and deafness.

Proteome-scale visual screening in budding yeast provides a functional catalog of plasma membrane repair proteins and reveals the coordinated cellular responses at the bud tip and the damage site.