Defective viral genomes (DVGs) and defective interfering particles (DIPs) represent naturally occurring variants of RNA viruses that are incapable of autonomous replication. In the presence of a ...

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi, only a ...

The technology, called the Viral-Engineered RNA-based Activation System (VERAS), hijacks the virus’s own replication machinery to switch on reporter or therapeutic genes precisely in infected cells.

A new possibility for managing cardiovascular disease through RNA interference (RNAi) gene therapies. As cardiovascular diseases continue to be the leading cause of death globally, this technology ...

COLUMBUS, Ohio – A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells ...

In the study, the researchers doubled the cancer-killing power of the RNA micelles by combining multiple copies of the chemo drug gemcitabine with a molecule called a small interfering RNA to silence ...