Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

The maintenance of genomic integrity in eukaryotic cells relies on the DNA damage checkpoint, a sophisticated signalling pathway that detects DNA lesions, transduces signals via sensor kinases and ...

The duplication of eukaryotic genomes is constantly challenged by lesions arising from endogenous metabolites and environmental agents. DNA damage tolerance (DDT) mechanisms enable replication to ...

In a new study, published in Cell, researchers describe a newfound mechanism for creating proteins in a giant DNA virus, comparable to a mechanism in eukaryotic cells. The finding challenges the dogma ...