Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...
Regulated helicase activation by DDK kinase is central for genome stability. However, how DDK phosphorylation primes the MCM2-7 double hexamer (DH) for Sld3-Sld7 binding and Cdc45 loading remained ...
DNA damage tolerance (DDT), activated by replication stress during genome replication, is mediated by translesion synthesis and homologous recombination (HR). Here we uncover that DDK kinase, ...
The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...
In a breakthrough discovery, published in Nature Communications, scientists from Queen Mary University of London in collaboration with researchers at Newcastle University and The Francis Crick ...
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...
Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...
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