During macropinocytosis, cells remodel their morphologies for the uptake of extracellular matter. This endocytotic mechanism relies on the collapse and closure of precursory structures, which are ...

The small GTPase Rab5 has well-established roles in membrane trafficking — for example, in receptor endocytosis. However, as Di Fiore and colleagues now show in Nature, it seems that Rab5 is also a ...