"Rather than building mitotic chromosomes from scratch, cells may use pre-existing chromatin domains as building blocks and reorganize them during mitosis." The review provides a new framework for ...

A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, offering fresh insight into how human cells build and maintain chromatin, ...

Chromosomes are masters of organization. These long strings of DNA fold down into an ensemble of compact structures that keep needed parts of the genome accessible while tucking away those that aren’t ...

Interphase domains as chromosome building blocks One key idea proposed in the review is that mitotic chromosomes may not be formed from scratch during cell division. Instead, pre-existing condensed ...