Figure 2: Donor CD44 is not required for engraftment of B-ALL–initiating cells. Figure 4: CD44-specific antibody treatment prolongs survival of recipients of BCR-ABL1–transduced progenitors. We ...

The molecule called CD44 is a transmembrane glycoprotein involved in cell to cell adhesion, interactions, and signaling. It is also a receptor of hyaluronic acid (HA) which is mechanistically involved ...

A research team affiliated with UNIST has made a significant discovery explaining why liver cancers associated with obesity and metabolic disorders tend to be more aggressive and less responsive to ...

Elevated salivary levels of CD44 and total protein (TP) can identify head and neck cancer patients with an increased risk for cancer recurrence, according to a study published online Aug. 15 in JAMA ...

Abstract Endotrophin (ETP) is a cleavage fragment of collagen VI α3 (COL6A3) that functions as a potent fibrotic and pro-tumorigenic factor. ETP is a ...

One of the main obstacles to successfully treating breast cancer is the cells' ability to change in ways that make them resistant to treatment. Understanding the cellular mechanisms that mediate this ...

Due to their rapid metastatic spread, pancreatic tumors are among the most aggressive types of cancer. Only three to five percent of patients have a survival rate of five years. A team of researchers ...

Protein biosignature identified by LC-MS/MS in classifying breast cancer and predicting tumor response to neoadjuvant therapy. Methods: Histological analysis of the breast was carried out on mounted ...

Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. Adjuvant cyclophosphamide, methotrexate, and fluorouracil versus fluorouracil, ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity. A ...

Studies in mice and humans show fibroblasts that overexpress HAS2 develop an aggressive phenotype. Scientists have implicated an interplay between overexpression of hyaluronan synthase 2 (HAS2) and ...