In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

Earlier methods to synthesize HAC relied on linking shorter DNA constructs into a larger chromosome within the cell in a process called multimerization. However, the genetic fragments tended to ...

The labs of Julian Sale and Jason Chin at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, U.K., have created two new tools critical for rapid genome construction at ...

When constructing bacterial artificial chromosomes (BACs), researchers must verify that they successfully inserted their gene of interest. Because these insertions are large, scientists perform their ...

The Telomere-to-Telomere (T2T) consortium, co-led by UC Santa Cruz Genomics Institute Associate Director Karen Miga and National Institutes of Health Genomics Research Institute Senior Investigator ...

Transposons are critical drivers of bacterial evolution that have been studied for many decades and have been the subject of Nobel Prize winning research. Now, researchers from Cornell University have ...

For sexual reproduction to yield healthy offspring, newly generated oocytes—immature egg cells—must receive the correct amount of DNA after cell division. This process of segregating chromosomes ...

Agrobacterium tumefaciens magnified 15,000 times in an image captured earlier this year with a scanning electron microscope at Iowa State University's Roy J. Carver High Resolution Microscopy Facility ...

Cost-effective oligo system design schematic. Each synthetic oligo consists of two oligos (oligo-A and oligo-B), one forward primer (Primer-A), and two reverse primers (Primer-B and Primer-C). (A) ...

PHILADELPHIA – Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory ...