Researchers at the Icahn School of Medicine at Mount Sinai have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to ...

Suven Life Sciences Ltd. has identified 5-HT1A receptor agonists and 5-HT2A receptor antagonists reported to be useful for the treatment of depression, insomnia, schizophrenia, bipolar and cognitive ...

Activation of the serotonin receptor, 5-HT1A, has been shown to regulate mood and cognition. The receptor is the primary target of buspirone, vilazodone, and gepirone, FDA-approved medications for the ...

Otsuka America Pharmaceutical Inc. has discovered new 3-pyrrolidine-indole derivative compounds and their deuterated forms acting as 5-HT1B/2A/2B receptor agonists and 5-HT1A partial agonists.

In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights ...

Serotonin receptor modulation underpins a wide spectrum of central nervous system functions and pathologies, from mood regulation to cognitive processing and motor control. Diverse receptor subtypes, ...

Serotonin 1A receptor is a G protein-coupled receptor of the serotonergic system expressed both presynaptically as an autoreceptor in raphe nuclei and postsynaptically across limbic and cortical ...

LSD and 5-MeO-DMT, a psychedelic found in the secretions of the Colorado River Toad, are known to mediate their hallucinogenic effects through the serotonin receptor 5-HT2A, though these drugs also ...

Mount Sinai researchers took detailed pictures of the serotonin receptor and clinically-validated drug target 5-HT1A using cryo-electron microscopy to show how the psychedelics LSD and 5-MeO-DMT and a ...