The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing ...
American Society of Clinical Oncology Technology Assessment on the Use of Aromatase Inhibitors As Adjuvant Therapy for Postmenopausal Women With Hormone Receptor–Positive Breast Cancer: Status Report ...
Developing small molecules that activate a subset of the body’s proteasomes to degrade defective proteins could be an effective way to treat neurodegenerative diseases and other complex disorders ...
Long viewed as mere trash recyclers inside the cell, proteasomes—at least those in neurons—just got a shiny makeover. According to a paper in the March 13 Nature Structural and Molecular Biology, ...
Our ever-increasing understanding of cancer cell biology has begun to provide a variety of new, and potentially drugable targets for the treatment of many forms of cancer. Nowhere else is this more ...
Booster Therapeutics is ready to open up a new arm of the proteasome after raising $15 million in seed funding to advance small molecules it says can degrade multiple types of harmful proteins. Rather ...
A new study shows vigorous exercise and fasting improve the ability of human and mouse cells to remove misfolded, toxic, unnecessary proteins. The findings reveal a previously unknown mechanism that ...
In the past year, cryoelectron microscopy has enabled scientists to crank out molecular structures of tau filaments, Aβ fibrils, and huntingtin aggregates. Now researchers led by Wolfgang Baumeister, ...
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